منابع مشابه
Progestins and breast cancer.
The relationship between the use of menopausal hormone therapy (ERT, unopposed estrogen therapy; HRT, combined estrogen and progestin therapy) and the development of breast cancer remains controversial. Mechanistic studies examining progestins in human breast cancer cell lines have demonstrated a biphasic cellular response to progesterone; initial exposure to hormone results in a proliferative ...
متن کاملInduction of prostate-specific antigen expression by synthetic progestins in patients with prostate and breast cancer.
To the Editor: In the October 1997 issue of the Mayo Clinic Proceedings (pages 932 to 934), Wehbe and associates reported an interesting phenomenon of a patient with prostatic carcinoma whose serum prostatespecific antigen (PSA) level decreased precipitously after discontinuation of megestrol acetate (MA) treatment. The same phenomenon was described previously by Dawson and McLeod. [1] In an ef...
متن کاملProgestins and recurrence in breast cancer survivors.
Menopausal hormone therapy use in breast cancer survivors is controversial, and clinical trials of this issue have proven diffi cult. Eight years ago, two separate randomized trials of this question were begun, but accrual diffi culties led to development of a merger with a joint analysis plans. In 2004 the trials were stopped early after an interim combined analysis of the pooled data found an...
متن کاملProgestins
ISSN: 1538-4101 (Print) 1551-4005 (Online) Journal homepage: http://www.tandfonline.com/loi/kccy20 Progestins: Pro-senescence therapy for ovarian cancer? Steffi Oesterreich, Robert Edwards & Anda Vlad To cite this article: Steffi Oesterreich, Robert Edwards & Anda Vlad (2013) Progestins: Prosenescence therapy for ovarian cancer?, Cell Cycle, 12:11, 1662-1663, DOI: 10.4161/cc.25072 To link to th...
متن کاملInduction of mammary cancer in mice without the mammary tumor agent by isografts of hypophyses.
It has been made clear by recent investigations that the presence of the mammary tumor agent (MTA) is not necessary for the development of mammary carcinoma in mice; the MTA is assumed to act only as an accelerator or intensifier. Thus, hormonal factors in the genesis of this type of tumor in mice have been recently emphasized, although it is realized that various other factors are involved as ...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1973
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1973.97